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AAA-10 is an orally active small-molecule inhibitor of gut bacterial bile salt hydrolases (BSH) used in research to probe microbial bile acid metabolism and downstream host effects.
Potent BSH inhibitor with IC50s of 10 nM (B. theta rBSH) and 80 nM (B. longum rBSH).
Inhibition in bacterial cultures: 74 nM (Gram-negative) and 901 nM (Gram-positive).
High purity (98.0%) and defined molecular weight (472.65 g/mol).
Soluble in DMSO (50 mg/mL) and compatible with several in vitro formulations.
Powder stability: -20°C up to 3 years, 4°C up to 2 years; in solvent stability varies.
Suitable for in vitro and in vivo formulation studies of bile acid metabolism.
Available in small solid quantities for research use.
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